ACTA FAC MED NAISS 2007; 24 (4): 201-208

Original article

COMPARISON OF REPRODUCTIVE CHARACTERISTICS, LABORATORY AND BIOHUMORAL MEDICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CARCINOMA AND UTERINE MYOMA

Predrag Vukomanovic
Milan Stefanovic
Ranko Kutlesic

Clinics of Gynecology and Obstetrics, Clinical Center Nis 
 

    SUMMARY

    Endometrial carcinoma is the most frequent malignant tumor, and uterine myoma the most frequent benign tumor of the female genital tract. The aim of this research was to compare:
- Biological – reproductive characteristics of patients with endometrial carcinoma and uterine myoma (time of menarche appearance, time of menopause appearance, parity, number of abortions, duration of reproductive life and time of illness in regard to menopause).
- Metabolic – biohumoral characteristics of patients with endometrial carcinoma and uterine myoma (values of cholesterol, triglyceride, glycemia, blood pressure and body mass).
    By adequate statistic analysis it was established that patients with endometrial carcinoma are statistically much older than the patients with uterine myoma, that menarche appears earlier, that menopause starts later, that reproductive life is longer, that the presence of insulin-dependent diabetes and accidentally detected hyperglycemia are more frequent, that they have cholesterol metabolism disorder and that body mass is bigger. It was also confirmed that the increase of systolic pressure is statistically important. Using the same method, it was found out that the number of labors and number of abortions, values of triglyceride and diastolic pressure are not statistically important.
    In conclusion, the reproductive characteristics, especially those associated to physiology and pathophysiology of menstrual cycle and metabolic – biohumoral events during life and especially before and after menopause, are important and can influence the appearance of endometrial carcinoma.
  

    Key words: endometrial carcinoma, uterine myoma, metabolic syndrome, menstrual cycle, menopause