ACTA FAC MED NAISS 2009; 26 (3): 135-141

Professinal article

RESIDUAL RENAL FUNCTION AND CARDIOVASCULAR COMPLICATIONS

IN PATIENTS ON PERITONEAL DIALYSIS

 

Dejan Petrović¹, Marina Avramović<sup>2

1</sup>Clinic for Urology and Nephrology, Center for Nephrology and Dialysis Clinical Center Kragujevac, Kragujevac, Serbia

²Clinic for Nephrology, Clinical Center Niš, Niš, Serbia

SUMMARY

Cardiovascular diseases are the leading cause of death in patients on maintenance dialysis, accounting for more than half of all deaths in patients on peritoneal dialysis. The patients on PD are at increased risk of cardiovascular morbidity and mortality due to the presence of traditional risk factors and non-traditional, uremic factors. The prevalence and impact of non-traditional risk factors is more pronounced with decline of residual renal function (RRF). Patients on PD without RRF had worse metabolic and cardiovascular profile (high grade anemia, resistance to erithropoietin, high Ca²⁺ x PO₄^3- product, worse inflammation and malnutrition, severe hypertension and left ventricular hypertrophy (LVH), and higher cardiovascular mortality compared to patients with preserved RRF. Preservation of the residual renal function could improve the cardiovascular outcome in patients on PD

Key words: residual renal function, peritoneal dialysis, cardiovascular complications