ACTA FAC MED NAISS 2009; 26 (4): 181-185

Original article

UDC 618.17-008.8:618.11-073.43

SIZE AND NUMBER OF SILVER-STAINED NUCLEOLAR ORGANIZER REGIONS AND SURVIVAL RATE IN PATIENTS WITH INTRAORAL CARCINOMAS

 

Zoran Pešić¹, Dragan Mihailović², Biljana Đorđević² , Slađana Petrović³, Dragan Krasić¹, Žaklina Mijović², Ivica Vučković

¹Department of Maxillofacial Surgery, Faculty of Medicine in Niš, Niš, Serbia
²Institute of Pathology, Faculty of Medicine in Niš, Niš, Serbia
³Institute of Radiology, Faculty of Medicine in Niš, Niš, Serbia


SUMMARY

Determination of future clinical behavior of carcinomas still present the subject of numerous investigations in which different clinical and histopathological findings have been analyzed. The value of argyrophilic nucleolar organizers (AgNOR) is one of them, and the association between their number and size and clinical findings have been analyzed in numerous investigations, on different tumors and different locations in human body. The aim of this investigation was to determinate the value of number and size of AgNOR in predicting the clinical behavior of intraoral carcinomas throughout survival rate of patients. The AgNOR size and number were analyzed in 50 patients with intraoral squamous cell carcinomas with different survival rates. By regression analysis, the relationship between AgNOR size and number and survival rate was not found. According to our results, it can be said that the values of AgNOR size and number in patients with intraoral carcinomas are not in correlation with survival rate.

Key words: carcinomas, intraoral,AgNOR