ACTA FAC MED NAISS 2013;30(3):123-127

Original article

UDC: 615.356:616.65-006

DOI: 10.2478/afmnai-2013-0003

Role of Vitamin D as an Anti-Proliferative Compound on Prostate Cancer

Ahmad Humayan Kabir¹, Ferdhos Khan², Mamunur Rashid Sarkar¹

¹Department of Botany, University of Rajshahi, Bangladesh

²Department of Biochemistry and Food Chemistry, University of Turku, Finland


Summary

The reason of prostate cancer is the mutation in the prostate cell. The present study was aimed at determining the effects of different concentrations of vitamin D on the anti-proliferative action of 24,25(OH)2D3 applied on LNCaP (cell line of human prostate cancer) cells. It was evident from the results that vitamin D having concentrations of 10^-9nM showed the best anti-proliferative action on prostate cancer cells (LNCaP cells) compared to other concentrations used. Most of the receptors were expressed at 10^-9nM resulting clear band in agarose gel image. Results also revealed that both nVDR and AR receptors (androgen receptors) were expressed well when treated with 10^-9nM and 10^-10nM concentrations of 24,25(OH)2D3. These findings confirm the potential use of vitamin D as an anti-proliferative compound against prostate cancer cells.

Key words: anti-proliferative effect, prostate cancer, receptor, LNCaP cells, vitamin D