ACTA FAC MED NAISS 2013;30(4):185-191

 Review article

UDC: 616.61-008.6:616.831-005.1

DOI: 10.2478/afmnai-2013-0010

Renal Dysfunction and Ischemic Stroke

Radovan Hojs^1,3, Tanja Hojs Fabjan^2,3

¹Clinic for Internal Medicine, Department of Nephrology, Maribor, Slovenia

²Department of Neurology, University Clinical Centre Maribor, Slovenia

³University of Maribor, Faculty of Medicine, Slovenia


summary

Chronic kidney disease (CKD) is an important worldwide public health problem and stroke represents a continuously evolving medical and social problem. Renal dysfunction carries a substantial risk for cardiovascular morbidity and mortality, the risk increases with a decline in kidney function. In the last 15 years the link between CKD and cerebrovascular disease has become more apparent. Nowadays, in dialysis patients suffering from stroke, ischemic subtype is present in approximately 70%. In high risk patients with different stages of CKD, renal dysfunction is clearly associated with subsequent ischemic stroke. In population-based studies, conflicting results have been reported. Furthermore, in patients with ischemic stroke renal dysfunction is associated with short- and long-term mortality. Authors present different studies published in this field and also add some of their own results.

Key words: cerebrovascular disease, chronic kidney disease, end-stage renal failure, mortality, renal dysfunction