ACTA FAC MED NAISS 2020;37(1):57-64

Original article

UDC: 616.45 008.6:616.12 008.331.1-07
DOI: 10.5937/afmnai2001057N

Primary Aldosteronism: An Analysis by Speckle Tracking

Echocardiography

Andryi Nykonenko¹, Iryna Zubryk¹, Oleksandr Podluzhnyi¹, Olrksandr Molodan²,
Sergii Bukhtii³, Oleksandr Nykonenko²

¹Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine
²State Department “Zaporizhzhya Medical Academy of Postgraduate Education of Ukrainian Ministry
of Health Care”, Zaporizhzhya, Ukraine
³Vinmec International Hospital JCI, Hanoi Vietnam Anesthesiology and Pain Management Department

summary

 

    Remodeling of the myocardium in patients with primary aldosteronism (PA) is mediated by the presence of mineralocorticoid receptors on the myocytes and fibroblasts. The goal of this study was to analyze the effect of arterial hypertension and metabolic disorders on the cardiovascular system in patients with PA.

             We recruited 54 patients with PA, 32 (61.1%) female and 22 (38.9%) male. The average age of the patients was 51.95 ± 13.77 years. There was a statistically significant negative correlation between the systolic blood pressure (SBP) and the longitudinal strain of the left ventricle (LV) at the basal level; a moderate negative correlation between the longitudinal strain of LV at the basal level and the aortic root diameter; a negative correlation between the circumferential strain of LV at the basal level and SBP, and a negative correlation between the circumferential strain of LV at the basal level and the aldosterone-renin ratio. The demonstrated correlations between SBP and longitudinal strain of LV at the basal level, diastolic blood pressure and circumferential strain of LV at the baselevel suggest thatleft ventricular hypertrophy in PA is preceded by the decrease not only in the longitudinal strain, as has been previously demonstrated, but also in the circular strain.

Key words: primary aldosteronism, hypertension, echocardioscopy, diagnostics