ACTA FAC MED NAISS 2020;37(3):267-273

Original article

 

UDC: 615.273:612.127

DOI: 10.5937/afmnai2003267B

 

Comparison of the Effects of Heparin 1000 and 5000 Units
on Arterial Blood Gases

 

Reza Borabadi1, Mostafa Rad2, Mohammad Hassan Rakhshani3, Mojtaba Rad4

 

 1Department of Nursing, Nursing and Midwifery School, Sabzevar University of Medical Sciences, Sabzevar, Iran
 2Department of Nursing, Nursing and Midwifery School, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran
 3Department of Biostatistics and eEpidemiology, School of Health, Iranian Research Center on Healthy Aging,
Sabzevar University of Medical Sciences, Sabzevar, Iran
 4Department of Medical Emergencies, School of Allied Medical Sciences,
Sabzevar University of Medical Sciences, Sabzevar, Iran

 

  

SUMMARY

 

               

                   Analysis of arterial blood gases is necessary for managing the respiratory and metabolic parameters of patients in the intensive care unit. The aim of this study was to compare the effects of heparin 1000 and heparin 5000 units on arterial blood gases in patients admitted to the intensive care unit. This study was a triple-blinded clinical trial. A total of 78 patients with head injury were randomly selected from the emergency department of a hospital in an urban area of Iran in 2017. Data was collected using a questionnaire and a checklist of laboratory parameters. Data was analyzed using descriptive and inferential statistical methods via the R software.

                Statistically significant differences in Na, SaO2, Ca, BEecf (p < 0.001), and HCO3, BEe and K were observed between the two groups (p < 0.01). No statistically significant difference between the values of PaCO2, PH and PaO2 in the two groups were reported (p > 0.05).

The results of this study confirmed that heparin 1000 and heparin 5000 units had no effects on respiratory parameters in analyzing arterial blood gases. However, the concentration of heparin had a significant effect on metabolic parameters for the analysis of arterial blood gases and electrolytes.

 

Key words: heparin concentration, arterial blood gas, electrolyte