ACTA FAC MED NAISS 2023;40(1):90-101|
ACTA FAC MED NAISS 2023;40(1):90-101 |
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Original article
UDC:
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Running title: AgNOR in Breast Lesions
Comparative Evaluation of Argyrophilic Nucleolar Organizer Regions
Parameters in Benign and Malignant Breast Tumors
Mehmet Koksal1,
Serap Dogan2, Recep Eroz3, Figen Ozturk4,
Ahmet Ozturk5, Nurhan Cucer6
1Erciyes University
Medical Faculty, Department of Biochemistry, Kayseri, Turkey
SUMMARY
Aim. The aim of the paper was to evaluate the AgNOR parameters for
the discrimination of benign from malignant breast tumors via a new
approach - the total AgNOR area/nuclear area (TAA/NA).
Material and methods. Three groups, consisting of control (n = 14),
benign (n = 18) and malignant (n = 28) participants were included in
the study. The AgNOR staining technique was performed and both mean
AgNOR number and TAA/NA ratio were evaluated.
Results. While the differences between the control and patient
groups were statistically significant for AgNOR number (p < 0.001),
it was not significant between the malignant group and the benign
group for mean AgNOR number (p > 0.05). For the ratio of TAA/NA, the
differences between the control and benign group (p < 0.001),
control and malignant group (p < 0.001), and malignant and benign
patient groups were significant. (p < 0.05).
Conclusion. We consider that the evaluation of the TAA/NA rate, when
compared with the AgNOR number, can be more sensitive and useful
tool for distinguishing benign from the malignant breast lesions.
Keywords: breast, breast cancer, nucleolar organizing regions, AgNOR
Corresponding author:
Mehmet Koksal
e-mail: mekoksal@hotmail.com