ACTA FAC MED NAISS 2023;40(4):402-414

Review article

UDC: 616.151.5-07:[616.98:578.834
 DOI: 10.5937/afmnai40-41219

                                             

Running title: Hemostatic Disorders in Patients with COVID-19

Pathophysiological and Laboratory Aspects of Hemostatic Disorders
in Patients with COVID-19

Jelena Đorđević1, Olgica Mihaljević1, Marijana Stanojević Pirković2, Isa Ardahanli3,
Milan Radović4,5, Batrić Babović6,7

 

1University of Kragujevac, Faculty of Medical Sciences, Department of Pathophysiology, Kragujevac, Serbia
2University of Kragujevac, Faculty of Medical Sciences, Department of Biochemistry, Kragujevac, Serbia
 3Seyh Edebali University, Faculty of Medicine, Department of Cardiology, Bilecik, Turkey
 4University of Belgrade, Faculty of Medicine, Department of Internal medicine, Belgrade, Serbia
 5University Clinical Center of Serbia, Clinic for Nephrology, Belgrade, Serbia
 6University of Montenegro, Faculty of Medicine, Department of Internal Medicine, Podgorica, Montenegro
 7Clinical Center of Montenegro, Clinic for Nephrology, Podgorica, Montenegro

 

  SUMMARY

  

Introduction/Aim. Although coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affects the respiratory system, the possibility of multisystem tissue and organ damage is not excluded. In severe forms of the disease, hematological disorders with the accompanying laboratory derangements often occur. The aim of the review was to describe and further improve our understanding of the possible pathophysiological mechanisms involved in hemostatic derangements in COVID-19 patients with accompanying laboratory findings.
 Material and Methods. A comprehensive investigation was conducted using keywords “COVID-19“, “SARS-CoV-2“, “hemostatic disturbances in COVID-19“, “laboratory findings in COVID-19“, in the PubMed, Google Scholar and Science Direct databases to determine the eligible studies.
Results. The most recognizable laboratory findings of these disorders include increase in the concentration of D-dimer values, prolonged prothrombin time with or without slight changes in the activated partial thromboplastin time, changes in the number of platelets according to thrombocytopenia or thrombocytosis (rarely), as well as an increase in the concentration of fibrinogen, usually in the initial stages of the disease.
Conclusion. The importance of COVID-19 coagulopathy is reflected in an increased mortality rate due to the high frequency of thromboembolic episodes, which can be the reason for multiorgan dysfunction syndrome.

 Keywords: COVID-19, hemostatic disorders, laboratory findings, SARS-CoV-2

 

Corresponding author:

Olgica Mihaljević

e-mail: vrndic07@yahoo.com