Introduction/Aim. During the SARS-CoV-2 pandemic, there was a
significant number of cases accompanied by thrombosis. The
precise pathophysiological mechanism remains unclear. The
importance of the fibrinolytic mechanism in maintaining
physiological hemostasis led us to explore its potential
contribution to COVID-19-induced thromboembolism. This study
aimed to identify changes in the hemostasis at the time of
admission of SARS-CoV-2-positive patients to the hospital and
their influence on the disease outcome.
Methods. The presented prospective study included 60, rt-PCR-confirmed
patients hospitalized in the Covid units of the Clinical Center
of Vojvodina. Platelet number, platelet aggregability, aPTT, PT,
fibrinogen, D-dimer, and Euglobulin Clot Lysis Time (ECLT) were
determined from blood samples. Participants were classified as
those with preserved and suppressed primary hemostasis, those
with physiological and increased thrombin activity, those with
preserved and decreased fibrinolytic activity, and those with
positive and negative disease outcomes.
Results. Forty-four positive outcomes were observed (73.3%),
while a negative outcome, including thromboembolic complications
and death was present in 16 subjects (26.7%). Unconditional
logistic regression revealed a mild negative influence of all
investigated parameters on the disease outcome. For ECLT, OR was
1.084 with 95%CI 1.023 – 1.160. The multivariate regression
model showed that of all the investigated parameters, only ECLT
was a significant predictor for negative outcome with a level of
p < 0.001.
Conclusion. The global assessment of the fibrinolytic mechanism
is a useful predictor of disease outcome in SARS-CoV-2-positive
patients at the moment of their admission to hospital.
Keywords: SARS-CoV-2, Covid-19,
hemostasis, fibrinolysis
Corresponding author:
Dejan Dobrijević
e-mail: dejan.dobrijevic@mf.uns.ac.rs