Acta Medica Medianae
Vol. 39
Number 1, Januar, 2000
UDK 61
YU ISSN 0365-4478
 

Kontakt:

Institute for Pulmonay Diseases,

18000 Niš
 

THE ROLE OF THE VIRUS RESPIRATORY INFECTIONS IN THE
PATHOGENESIS OF THE ASTHMATIC EXARCEBATIONS

Miloš FILIPOVIĆ¹, Boiis ĐINDIĆ², Svetlana PLJASKIĆ-KAMENOV³ i Olivera DUNJIĆ²

Institute for Pulmonay Diseases¹,

Institute for Pathologic Physiology of the Faculty of Medicine²

Medical Center, Niš³
 

The virus infections of the respiratory pathways represent an important cause of the emergence of the symptoms of the puffing (wheezing) in the lungs of the patients of all age groups. In the patients suffering from asthma the virus respiratory infections are the main causes of asthmatic exarcebations. In 80 to 85 % of the school children and in 50 % of the adult asthmatics, the exarcebations are caused by the respiratory virus infection while the most frequent cause is the rhinovirus. It is believed that in the pathogenesis of the virus-induced asthmatic exarcebations the following mechanisms are involved: the damage of the epithelium, the inflammation increase in the respiratory pathways, the disturbance of the small respiratory pathways' geometry, the disturbance of the nerve controlling mechanisms and the disturbance of the IgE synthesis regulation.

Key words: Asthmatic exarcebations, virus respiratory infections, pathogenesis