Acta Medica Medianae
Vol. 40
No 1, 2001
UDK 61
YU ISSN 0365-4478
Contact:
Vuka
KATIĆ
Institute for Pathology of the Clinic Center |
THE ROLE OF
THE HYPOTHALAMUS LESIONS IN WOMEN'S STERILITY - AN EXPERIMENTAL STUDY
Vuka KATIĆ, Stevo
NAJMAN, Telena ŽIVANOV-ČURLIS, Vladmila BOJANIĆ, Marko MATIJAŠ and
Snežana JANČIĆ
Institute for
Pathology of the Clinic Center, Institute for Biology with Genetics of
the Faculty of Medicine and Clinic for Neurology of the Clinic Center,
Niš
The anovulatory
cycles and amenorrhea in the female patients with Cushing's syndrome,
coupled with sterility, the Cushingoid type of obesity in our experiment
as well as contradictory data about sterility of rats and mice in the
identical experiment represent the reasons for studyng the function and
morphology of the ovaries in the animals treated by monosodium glutamate
(MSG).
The experimental group of the black mice C57BL/6.T of the female gender
has been treated by an intraperitoneal solution of MSG in the dose of
4,4 mg/g of the body-weight from the first to the ninth day after birth.
The coupling of the treated females with the untreated males was done
after 90 days of age; these females were sacrificed 120 days after
birth. The ovaries were removed and fixed in the solution of 10%
fonnaldehyde, manually treated and cut on the microtone. The paraffin
sections were colored by HE, PAS and Van Giesen methods. The identical
procedure was also appliced to the control group of animals of both
sexes.
All the treated animals were sterile. The ovaries were enlarged, cystic,
without yellow or albinic bodies. In the control females, there were
Graf follicles found in various phases of maturation as well as
luteinized stroma.
The paper discusses the disturbance of the hypothalamus-hypophysis-gonad
axis caused by the damage of the hypothalamus regions secreting various
"releasing" hormones.
Key words:
Hypothalamus obesity,
monosodium glutamate, cystic ovaries |