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Acta Medica Medianae
Vol. 40
No 3, 2001
UDK 61
YU ISSN 0365-4478


Institute for pathophysiology of the Faculty of Medicine, Niš



Boris DINĐIĆ, Stojan RADIĆ, Slobodan ANTIĆ and Dušan SOKOLOVIĆ


Institute for pathophysiology of the Faculty of Medicine, Niš


Despite some research studies pointing to the importance of poor glycoregulation and the emergence of the coronary heart disease (CHD) in the patients suffering from diabetes, the strength of relation between these two phenomena is still not clear enough.
The aim of the paper is to examine the importance of the glycoregulation disturbance for the emergence of a coronary heart disease in insulin-independent patients. The methods for estimating glycoregulation comprised: the determination of a morning glycemia on an empty stomach, the determination of a daily glycemia profile by taking 5 capillary blood samples in a day and determining the medium value of the daily profile.
By comparing the glycemia profiles in the examined patients a statistically important difference among the medium glycemia values was found in each of the examined groups. In the dyslipodemic patients with a CHD the glycemia values were considerably larger in all the daily measurements and the medium daily profile of glycemia (MBG) amounted to 9.77+2.47 mmol/1, while in the patients without any coronary disease they amounted to 7.8+1.74 mmol/1. An important correlation was found between the triglyceride values and the morning glycemia (C=0.48) in the diabetes patients with the CHD, while in the diabetes patients without any CHD a positive correlation of the MBG values with cholesterol (C=0.54) and triglycerides (C=0.48) was found. A strong negative correlation in this group was shown for the HDL cholesterol (C=0.7). All this reveals a joint relation between hyperglycemia and lipid disturbances with a cumulative effect upon the emergence of the CHD in the NIDDM patients.


Key words: glycoregulation, coronary heart disease, diabetes