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Acta Medica Medianae
Vol. 40
No 3, 2001
UDK 61
YU ISSN 0365-4478
Contact:
Boris DINĐIĆ
Institute for
pathophysiology of the Faculty of Medicine, Niš
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IMPORTANCE OF THE GLYCOREGULATION IN THE CORONARY HEART DISEASE
PATHOGENESIS IN DIABETES MELITUS
Boris DINĐIĆ,
Stojan RADIĆ, Slobodan ANTIĆ and Dušan SOKOLOVIĆ
Institute for
pathophysiology of the Faculty of Medicine, Niš
Despite some research
studies pointing to the importance of poor glycoregulation and the
emergence of the coronary heart disease (CHD) in the patients suffering
from diabetes, the strength of relation between these two phenomena is
still not clear enough.
The aim of the paper is to examine the importance of the glycoregulation
disturbance for the emergence of a coronary heart disease in
insulin-independent patients. The methods for estimating glycoregulation
comprised: the determination of a morning glycemia on an empty stomach,
the determination of a daily glycemia profile by taking 5 capillary
blood samples in a day and determining the medium value of the daily
profile.
By comparing the glycemia profiles in the examined patients a
statistically important difference among the medium glycemia values was
found in each of the examined groups. In the dyslipodemic patients with
a CHD the glycemia values were considerably larger in all the daily
measurements and the medium daily profile of glycemia (MBG) amounted to
9.77+2.47 mmol/1, while in the patients without any coronary disease
they amounted to 7.8+1.74 mmol/1. An important correlation was found
between the triglyceride values and the morning glycemia (C=0.48) in the
diabetes patients with the CHD, while in the diabetes patients without
any CHD a positive correlation of the MBG values with cholesterol
(C=0.54) and triglycerides (C=0.48) was found. A strong negative
correlation in this group was shown for the HDL cholesterol (C=0.7). All
this reveals a joint relation between hyperglycemia and lipid
disturbances with a cumulative effect upon the emergence of the CHD in
the NIDDM patients.
Key words:
glycoregulation,
coronary heart disease, diabetes |
