Acta
Medica Medianae
Vol. 41
No 1, 2002
UDK 61
YU ISSN 0365-4478
Kontakt:
Milan
Jovanović
Surgical Clinic ofthe Clinic Center, Nis
home adress:
Niška Banja, 30 Vidoja Jovanovića street
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PROTECTIVE POSSIBILITIES OF THE
AUTOTRANSPLANTATION OF THE INJURED SPLEEN
Milan JOVANOVIĆ, Goran STANOJEVIĆ, Miroslav STOJANOVIĆ, Milan VIŠNJIĆ,
Jovica JOVANOVIĆ, Branka KOCIĆ, Biljana MILJKOVIĆ, Miroslav
STOJILJKOVIĆ, Dragojlo GMIJOVIĆ, Miomir PEŠIĆ, Miloš ROSTOV, Goran
STEVANOVIĆ and Predrag ĐORDEVIĆ
Surgical Clinic of the Clinic Center, Institute for
Health Protection and the Military Hospital, Niš
The spleen auto-transplantation is a conserving method that is indicated
in the most serious injuries of the spleen followed by the jarring of
the parenchyma or total devascularization of the organ when it is
impossible to apply any other conserving procedure.
After multiple devascularizing injuries of the spleen of the fifth
degree were induced, 20 dogs were subjected to auto transplantation of
the organ while the same number of the animals was primary
splenectomized. Two months and a half after the conserving operation,
that is, splenectomy, all the animals (from both the groups) were
exposed to an intravenous inoculation of the sublethal doses of
pneumococci for the sake of perceiving immunological efficiency of the
conserved tissue and comparing the mortality rate from the pneumococci
sepsis between the two examined groups.
The positive hemoculture and the logarithmic increase of the number of
diplococcus in the blood samples are registered in all 40 animals. A
higher mortality rate and a highly significant increase of the bacteria
in blood are registered in the group of splenectomized animals with
respect to the autotransplanted group.
The obtained results point to the immunoprotective advantage of the
con-serving actions with respect to the classical splenectomic
procedure.
Key words: Spleen injuries, conservation, immunology |