Acta Medica Medianae
Vol. 41
No 1, 2002
UDK 61
YU ISSN 0365-4478
Kontakt:
Slavimir Veljković,
Institut za fiziologiju Medicinskog fakulteta u Nišu;
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EFFECT OF THE AREA POSTREMA
DESTRUCTION UPON THE CARDIOVASCULAR EFFECTS OF THE INTRACEREBRO-
VENTRICULARLY INJECTED ESTERASE OF CHOLINE, PILOCARPINE AND NICOTINE
Slavimir VELJKOVIĆ, Mirjana RADENKOVIĆ, Snežana
CEKIĆ, Rade ČUKURANOVIĆ, Dragana VELIČKOVIĆ, Suzana JOVANOVIĆ, Milan
ĆIRIC and Ranka SAMARDŽIĆ
Institute for Physiology of the
Faculty of Medicine, Niš
The effect of the area postrema destruction upon the cardiovascular
effects caused by the intracerebro-ventricularly injection of esters of
choline, pilocarpine and nicotine has been analyzed. In the animals with
the destroyed area postrema the intracerebro-ventricularly injected
esters of choline (carbahol, betanechol and metacholine), pilocarpine
and nicotine have induced a statistically significant smaller
hypotension effect than in the animals with their area postrema intact.
The hypotension effect of the intracerebro-ventricularly injected
acetylcholine is not significantly changed in the animals with the
destroyed area postrema. On the basis of the obtained results the
authors conclude that the hypotension effects caused by the central
stimulation of the nicotine and muscarine receivers are at least
partially realized by the involvement of the nerve structures of the
given area.
Key words: Hypotension effect, area postrema, esters of choline,
pilocarpine, nicotine |