Acta Medica Medianae
Vol. 41
No 3, 2002
UDK 61
YU ISSN 0365-4478

 



Contact:
Dejan Ursulović
Institute for Work Medicine of the Clinic Center Serbia in Belgrade

HYPERSENSITIVE RHINITIS WITH NASAL POLYPOSIS - EFFECTS OF TREATMENT WITH LOCAL CORTICOSTEROID UPON THE CLINIC PARAMETERS OF THE ILLNESS

Dejan Ursulović, Ljiljana Janošević, Slobodanka Janošević and Miško Živić

Institute for Work Medicine of the Clinic Center and Institute for Otorhinolaryngology and Maxi facial Surgery of the Clinic Center of Serbia in Belgrade,     

Institute for Social Medicine, Statistics and Research of the Faculty of Medicine, Belgrade and the Clinic for Otorhinolaryngology of the Clinic Center, Nis

          Hypersensitive rhinitis coupled with nasal polyposis is always followed by the following symptoms, namely, nasal pruritus, sneezing, nasal secretion and nasal ob­struction. The aim of our research was to determine the local corticosteroid effect upon the mentioned symptoms of the patients suffering from hypersensitive rhinitis coupled with bilateral moderate nasal polyposis.

          The research was prospective and controlled. There was a total of 13 examined patients suffering from hypersensitive rhinitis coupled with bilateral moderate nasal polyposis; out of this number 10 patients were subjected to local corticosteroid ther­apy while in 3 patients no therapy was applied whatsoever. The therapy consisted of beclomethasone dipropionate treatment in water nasal spray. The daily dose was 400 micrograms; it was continually delivered in 6 months. The patients of both the groups were controlled by a series of othorinolaringological examinations: before the ther­apy (basal), after six-week therapy, after three-month therapy and after six-month therapy. The followed nasal symptoms are graded regarding their intensity while their average score was intra group and inter-group compared.

          In the group of the treated ones the research results after six-week therapy show a considerable reduction of the average symptom score with respect to the basal state. Further treatment, that is, after three-month and six-month therapy, did not show any considerable change. In the non-treated group during the follow-up period the average symptom score did not considerably change.

          To conclude it can be said that the local beclomethasone dipropionate therapy represents an important medicament, of the first therapy rank with hypersensitive rhinitis compelled with bilateral moderate nasal polyposis.

            Key words: Beclomethasone dipropionate, local corticosteroids, nasal polyposis, rhinitis