Acta Medica Medianae
Vol. 42
No 2, April, 2003
UDK 61
YU ISSN 0365-4478

 

Contact:
Milan Cirić
Institut za fiziologiju Medicinskog fakulteta
Brace Tasković 81,
18000 Niš, Srbija i Crna Gora
Tel.: 018/326-644 lok. 132

THE EFFECTS OF ENALAPRIL ON UREA AND CREATININE SERUM CONCENTRATION AND PAS COLORING MORPHOLOGICAL CHANGES IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY

Milan Ćirić, Slavimir Veljković, Mirjana Radenković, Snežana Cekić, Dragana Veličković, Milkica Nešić, Suzana Branković i Nenad Stojiljković

Institute of phiziology Faculty of Medicine in Nis

The effects of Enalapril on glomerular changes and desquamation of tubular epithel in rats were analyzed in Gentamicin nephrotoxicity. It was detected necrosis and epithel desquamation of proximal tubules and degenerative changes in glomerular at animals treated by Gentamicin (100 mg/kg body mass/24 h). Nephron morphological changes were more intensive and extensive by simultaneous treatment of Gentamicin and Enalapril. In animals, treated by Gentamicin it appeared the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. The combination of Enalapril and Gentamicin resulted bigger kidney damage then Gentamicin itself, so the level of urea concentration in serum (p<0,001) and creatinine concentration (p<0,05) was higher in the third experimental group. Our biochemical results are according to the PAS coloring morphological changes found in kidney. Consequently, our findings support hypothesis that Enalapril causes exacerbating of Gentamicin nephrotoxicity. Acta Medica Medianae 2003; 42 (2): 13-16.

Key words: Enalapril, desquamation of proximal tubules epithel, PAS coloring, Gentamicin nephrotoxicity