Acta
Medica Medianae
Vol. 42
No 2, April, 2003
UDK 61
YU ISSN 0365-4478
Contact:
Milan Cirić
Institut za fiziologiju Medicinskog fakulteta
Brace Tasković 81,
18000 Niš, Srbija i Crna Gora
Tel.: 018/326-644 lok. 132
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THE EFFECTS OF ENALAPRIL ON
UREA AND CREATININE SERUM CONCENTRATION AND PAS COLORING MORPHOLOGICAL CHANGES
IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY
Milan Ćirić,
Slavimir Veljković,
Mirjana Radenković,
Snežana Cekić,
Dragana Veličković,
Milkica Nešić,
Suzana Branković i
Nenad Stojiljković
Institute of phiziology Faculty of Medicine
in Nis
The effects of Enalapril on glomerular changes and desquamation
of tubular epithel in rats were analyzed in Gentamicin nephrotoxicity. It was
detected necrosis and epithel desquamation of proximal tubules and degenerative
changes in glomerular at animals treated by Gentamicin (100 mg/kg body mass/24
h). Nephron morphological changes were more intensive and extensive by
simultaneous treatment of Gentamicin and Enalapril. In animals, treated by
Gentamicin it appeared the increasing of urea (p<0,001) and creatinine (p<0,001)
comparing to the control group. The combination of Enalapril and Gentamicin
resulted bigger kidney damage then Gentamicin itself, so the level of urea
concentration in serum (p<0,001) and creatinine concentration (p<0,05) was
higher in the third experimental group. Our biochemical results are according to
the PAS coloring morphological changes found in kidney. Consequently, our
findings support hypothesis that Enalapril causes exacerbating of Gentamicin
nephrotoxicity. Acta Medica Medianae 2003; 42 (2): 13-16.
Key words: Enalapril, desquamation of proximal tubules
epithel, PAS coloring, Gentamicin nephrotoxicity
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