Acta
Medica Medianae
Vol. 42
No 2, April, 2003
UDK 61
YU ISSN 0365-4478
Contact:
Slavica Veselinović
Klinika za onkologiju Kliničkog centra,
Braće Tasković 48 18000 Niš,
Srbija i Crna Gora
Tel.: 531-120,
e-mail: vesa@bankerinter.net
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INCIDENCE AND CLINICAL
CHARACTERISTICS OF BONE METASTASES IN PATIENTS WITH BREAST CARCINOMA
Slavica Veselinović,
Stojan Radić,
Slađana Filipović,
Miodrag Projević,
Milan Burić,
Anica Stanić i
Sonja Mardikijan-Ignjatijević
Klinika za onkologiju Kliničkog centra u Nišu
High incidence of breast carcinoma and mortality that it produces, reqire the
analysis of incidence and clinical characteristics of bone metastases, which are
one of the commonest complication of this disease.
Analysis encompassed 380 women with breast carcinoma producing metastases
treated in Oncology Clinic in Niš, in period from 1996 to 1998. Out of overall
number of patients, 172 (45,3%) had their bone system registered as a location
of metastases. It is evident and statistically significant that the greatest
number of patients with bone metastases were from tumor grade I and II.
Significantly greater incidence of positive estrogen and progesterone receptors
was registered in patients with bone metastases compared to the patients with
bone metastases in visceral organs (p<0,001). Analysis of changes in bone
structure in patients with bone metastases revealed that greater number had
osteolytic type of changes (50,6%). It is evident that the most fregent place of
bone lesion is pelvis and lumbal-sacral vertebrae, while the most frequent
skeletal complication was pain in the bones (84,4%).
Compared findings concerning survival time since the beginning of the disease
until the appereance of the first metastases, in patients with bone and visceral
metastases revealed significantly more favorable outcome in patients with bone
metastases (p<0,001).
High incidence of bone metastases in patients with breast carcinoma,confirmed by
this clinical research, highlights the need for adequate screening of all
patients with breast carcinoma with purpose of early detection of initial
lesions and early application of adequate therapy. Acta Medica Medianae 2003; 42
(2): 49-53.
Key words: breast carcinoma producing metastases, bone metastases,
clinical characteristics
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