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Acta
Medica Medianae
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PILOT STUDY ON ACID BURNS OF THE OESOPHAGUS IN GUINEA PIGS Valentin K. Stojanov* and Borislav D. Dimitrov**
Correct time determination for beginning of
the first bouginage in cases with Stomatoesophagitis corrosiva is probably the
most important step for successful outcome of treatment procedures. The aim of
this study was to describe patterns of acid burns of the oesophagus in Guinea
pigs. We tested 20 animals (mean initial weight of 520 g on average) divided
into two groups: Group 1 (subjected to 98% H2SO4) and Group 2 (15% H2SO4).
Changes in weight, pathohistological findings (biopsy), time and cause of death
(after International Classification of Diseases - 9th revision) were
analysed. The results revealed that animals from Group 1 died about the day 6
from ingestion of the acid with mean decrease of weight of 9.83% as the
difference with the initial one was statistically significant (p<0.05)
Peritonitis (ICD9 Dx:567) was the cause of death with highest frequency. During
the study period of 1 month, Peritonitis and Mediastinitis acuta (Dx:518) were
pathohistological diagnoses with highest frequency. Only 3 animals from Group 2
died during the period of observation while the rest (n=7) survived afterwards.
The relative risk of dying up to the day 9 incl. after ingestion of 98% against
15% H2SO4 was 9 (p<0.05). The histological analysis on the
day 10 from ingestion revealed severe necrotic changes of all layers of the
ossophageal wall. Our conclusion from these preliminary results was to sustain
the idea to refrain from early bouginage in cases with massive damage of the
oesophagus by concentrated acids. Above results might be found useful in
planning larger experimental studies on acid burns of the oesophagus in the
future. Acta Medica Medianae 2003; 42 (2): 5-8. |