Aleksandar Kostic, Milorad Babic, Dragan Mihailovic and Zoran Milenkovic

Clinical of neurology sargery, Clinical Center, Nis*
Institute of pathology, Clinical Center,  Nis**

    Astrocytoma represents the most frequent pathohistological finding in patients operated from primary brain tumor. Each grade of this kind of tumors has unique initial mechanisms of developing, biological behavior and variable response to undertaken surgical and oncological treatment. Tumor grade is, probably, the most important survival factor in patients operated from the brain astrocytoma. In our study, he have examined 63 pathohistological samples obtained from patients, of both sexes operated at Neurosurgical Clinic in Nis, from the beginning of 2000. until the end of 2001. Health condition of the patients has been observed until March 2003. We have compared survival of two groups of the astrocytoma operated patients: first-with high grade (WHO gr. III and IV) and the second with low grade astrocytomas (WHO gr. II and I). There were 49 high grade and 14 low grade astrocytomas. Average survival was 43 weeks and 209 weeks, respectively. We have found high statistical significance between survival and astrocytomas grade in the operated patients. Acta Medica Medianae 2004; 43 (1):65 – 69.

    Key words: astrocytoma, tumor grade, survival