Acta Medica Medianae
Vol. 43
Number 1, Januar, 2004
UDK 61
YU ISSN 0365-4478

 

Contact:
Milan Ćirić
Institute of physiology, Faculty of Medicine
81 Dr Zorana Đinđića Street,
18000 Niš
Serbia and Montenegro
Phone.: 018/326-644, lok. 132

BIOCHEMICAL AND MORPHOLOGICAL RENAL CHANGES IN GENTAMICIN NEPHROTOXICITY

Milan Ciric, Slavimir Veljkovic, Mirjana Radenkovic, Snezana Cekic,
Dragana Velickovic, Milkica Nesic and Suzana Brankovic

Institute of physiology, Faculty of Medicine, Nis

    The aim of the research is to analyze glomerular and tubular epithel changes in Gentamicin nephrotoxicity. Degenerative changes were detected in cortex of animals treated by Gentamicin were detected (100 mg/kg body mass/24 h). The nephron morphological changes were the most intensified in tubular system: as desquamation of proximal tubules and necrosis in glomerular capillary loops. In animals, treated by Gentamicin the decreasing of sodium serum concentration (p<0,01) and potassium (p<0,05) took place while there was the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. Our biochemical and morphological findings support hypothesis that Gentamicin causes exacerbation of renal function and lead to kidney insufficiency. Acta Medica Medianae 2004; 43(1): 23–27.