Boris Djindjic, Ruzica Jankovic, Todorka Savic and Vladmila Bojanic

    Low concentration of plasma lipoproteins (hypolipoproteinemia) presents decreasing concentrations of all or particular lipids components. Classification of hypolipoproteinemia (hypoLP) divides them into: primary (hereditary) and secondary. Primary hipoLP are rare diseases and their main characteristic is disorder of apolipoproteins synthesis, which leads to low serum cholesterol concentration. Secondary hipoLP are presented in many diseases. They have diagnostic, prognostic significance and present good therapeutic marker. However, modern therapeutic approaches for aggressive lipid lowering pointed out many questions about physiological limits for cholesterol lowering. These approaches, also, open many questions about consequences of low serum concentration of total cholesterol and triglicerides. Acta Medica Medianae 2004; 43 (1):43 – 47.

    Key words: hypolipoproteinemia, statins, adverse effects