Acta Medica Medianae
Vol. 43
Number 2, April, 2004
UDK 61
YU ISSN 0365-4478

Contact:
Marina Đorđević
Clinic of infektology, Clinical center,
50 Dr Zoran Djindjic Street,
18000 Nis, Serbia and Montenegro
Tel.: 018/590-993

THE RARE MANIFESTATION OF BRUCELLOSIS

Marina Djordjevic¹, Milijanka Krstic¹, Branko Lako², Milos Petrovic³ and Bozidar Djukic⁴

Clinic of infektology, Clinical center, Nis¹
Institute of microbiology, VMA, Belgrade²
Institute of veterine, Nis³
INEP, Zemun⁴

    Objective: The case report of rare form of Brucellosis named neurobrucellosis with clinical feature of meningoencefalitis.
    Methods: Rapid agglutination reaction-BAB, classic agglutination Wright, ELISA and Western blot test were used for serological conformation of the disease.
    Results: An increasing antibody titer from 1:320 to 1:640, regarding brucella antigen was obtained.After one year, a patient didn't have any difficulties, clinical state and biohumoral status were all right. Serologically, BAB was positive and Wright was 1:20. ELISA was positive in IgG class, and negative in IgM class.Western blot was positive.
    Conclusion: ELISA represents the most reliable and the most sensitive method for determinating the class of immunoglobulins and for following disease evolution in patients with neurobrucellosis and/or chronic brucellosis. Acta Medica Medianae 2004; 43: 69-72.

Key words: brucellosis, neurobrucellosis, diagnosis, therapy