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Acta
Medica Medianae
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THE EFFECTS OF VERAPAMIL ON SODIUM AND POTASSIUM SERUM CONCENTRATION AND HE COLORING MORPHOLOGICAL CHANGES IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY Milan Ciric*, Slavimir Veljkovic*, Mirjana Radenkovic*, Snezana Cekic*, Dragana Velickovic*, Milkica Nesic*, Suzana Brankovic* and Boris Djindjic** Institute of fiziology,
Faculty of Medicine, Niš*
The effects of verapamil on glomerular changes and tubular system in rats were
analyzed in gentamicin nephrotoxicity. Epithel desquamation of proximal tubules
and degenerative changes in glomerular was detected in animals treated by
gentamicin (100 mg/kg body mass/24h). In animals, treated by gentamicin, the
decreasing of sodium and potassium appeared in comparison to the control group.
The combination of verapamil and gentamicin resulted in lower kidney damage than
gentamicin itself, so the level of sodium concentration in serum and potassium
concentration was higher in the third experimental group. Nephron morphological
changes were lower by simultaneous treatment of gentamicin and verapamil.
Consequently, the obtaind results support hypothesis that verapamil is a
protective factor in gentamicin nephrotoxicity. Acta Medica Medianae 2004;
43(2): 9-12. |