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Acta
Medica Medianae Contact:
Copyright 2004 by Faculty of Medicine, University of Niš |
PENICILLIN EPILEPSY IN RATS
Slobodan Dragić*
and Voja Pavlović**
Institute of
Physiology, Faculty of Medicine, Priština*
The purpose of this study is to test, in a model of experimental penicillin
epilepsy, a hypothesis of primary and dominant role of cortex in genesis of
epileptic discharges, by using recordings of electrocorticograms (EcoG). The
experiments were made with around two and a half old male rats. The rats were
divided into four groups of five animals each. In the case of the first group,
antibiotics were applied intraperitoneally (i.p.). Epileptic generalized
discharges of this group were not registered until administering a dosage of
antibiotics higher than 1.8 x 106
IU/kg. In the second group, application of a dosage of 1.2 x 106
IU/kg resulted in individual discharges. In the third group,
antibiotics were applied intracortically (i.c.) in a dosage of 50 IU and caused
individual discharges without big seizures. The fourth group needed a dosage of
100 IU/kg of penicillin applied i.c. to develop a big seizure. Discharges in the
first three groups were registered first as unilateral with a subsequent
development of bilateral synchrony. In the case of the fourth group, immediately
and abruptly after the application of penicillin big seizures developed
violently and repeated several times. We consider that the very implantation of
electrodes provokes occurrence of discharging.
Acta Medica Medianae 2004; 43 (4):
19–23. Key words: experimental epilepsy, penicillin, rats |