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Acta
Medica Medianae Concat:
Copyright 2004 by Faculty of Medicine, University of Niš |
OXIDATIVE STRESS, STRESS PROTEINSAND ANTIOXIDANTS IN EXERCISE
Dragan Radovanović* and Goran Ranković**
Faculty of Physical Education, Niš*
Exercise appears to increase reactive oxygen
species (ROS), which can result in damage to cells. Potencial sources of ROS in
skeletal muscle fibers during exercise include the mitochondrial respiratory
chain, xantine oxidase production of superoxide, enzymatic arachidonic acid
oxygenation, nitric oxide synthesis, catecholamine oxidation, and
neutrophil-induced oxidative burts. Stress proteins (SPs) represent one of the
general molecular protective mechanisms that enable cell and whole organisms to
survive stress. The exact relationship between exercise, ROS and SPs remains
unclear. Antioxidant supplements have been touted by manufacturers as a means
for athletes to perform better, recover more quickly and fully from endurance
exercise, or allow them to train more strenuously. At present, data are
insufficient to recommend antioxidant supplements for athletes or other persons
who exercise regularly. However, no one questions the importance of ingesting a
diet rich in antioxidants for all who exercise and train regularly.
Acta Medica Medianae 2004;
43(4): 45–47. Key words: exercise, antioxidant, oxidative stress, stress protein, skeletal musc |