SODIUMNITROPRUSSIDE AS
A HYPOTENSIVE AGENT DURING GENERAL
ANAESTHESIA AND PLASMA LEVEL OF NO
The study included 30 patients who received general
anaesthesia due to chronically inflammatory disease of the middle ear.
The aim of the study was determination of plasma level of NO
if we use sodium nitroprusside (SNP) as a hypotensive agent and the correlation
between plasma level of NO and mean arterial pressure (MAP).
Material: 30 patients were divided in two groups: 15 patients
received general anaesthesia with continuous intravenous infusion of sodium
nitroprusside as a hypotensive agent and 15 patients received general
anaesthesia without hypotensive agent.
The level of MAP during hypotensive anaesthesia was between
60 and 70 mmHg (8-9kPa).
Method: enzymatic method according to Conrad.
The results have shown that general anaesthesia with
continuous intavenous infusion of SNP produces higher plasma level of NO than
plasma level of NO in patients who received general anaesthesia without
hypotensive agent.
The type of correlation between NO and MAP is negative, which
means that if the level of MAP dicreases, the level of NO increases. Acta Medica
Medianae 2005;44(1): 5-9.
Key words: plasma level of NO, sodium nitroprusside
(SNP) hypotensive anaesthesia, middle ear surgery