Acta Medica Medianae
Vol. 46, No 4, December, 2005 UDK 61 YU ISSN 0365-4478
Contakt:
Goran
Ilić
Zavod za sudsku medicinu Kliničkog centra
Bulevar dr Zorana Đinđića 81
18 000 Niš
E-mail: gilke@medfak.ni.ac.yu
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cHRONIc INTRAVENOUS HEROIN ABUSE AND HEPATIc
AMYLOIDOSIS
Goran Ilić, Jovan Stojanović, Lidija Kostić-Banović i Radovan
Karadžić
Zavod za sudsku medicinu Kliničkog centra u Nišu
A few data on
systemic amyloidosis in heroin abusers as well as the development of
liver
amyloidosis, as its important target, are the reasons for this
examination. The liver amyloidosis
was found in 22,5 % of autopsies and it was very often associated
with liver alcoholic
disease. Amyloid deposits were found in the walls of arteries and
arterioles, as well as inside
portal and lobular connective tissue frame. The role of
macrophage-derived enzymes and cytokines,
together with a genetically determined strucural abnormality in the
SAA molecule in the
genesis of systemic amyloidosis, was discussed. Acta Medica Medianae
2005;44(4): 85 – 88.
Key words: heroin abusers, amyloidosis, liver
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