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Acta Medica Medianae
Voja
Pavlovic
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AScORBIc AcID MODULATES SPONTANEOUS THYMOcYTE APOPTOSIS
Voja Pavlović, Snežana Cekić, Vladmila Bojanić, Nenad Stojiljković i Goran Ranković
Institute of Physiology, Faculty of Medicine, Nis1
The aim
of the paper was to analyze the effect of various concentrations of
ascorbic acid on spontaneous apoptosis of lymphocytes. About 58% of
all thymocytes are subjected to a spontaneous apoptosis, after
24-hour cultivation in the complete medium. The number of apoptotic
thymocytes was much lower in the culture with different
concentrations of ascorbic acid. The most dramatic effect was
detected in the culture with the highest concentration of ascorbic
acid (10000 µg/ml). In this culture, the number of apoptotic
thymocytes was about 32%. These results, compared with the results
of spontaneous apoptosis, show that the most significant inhibition
of apoptosis was detected in the culture with 10000 µg/ml of
ascorbic acid. High concentration of ascorbic acid can inhibit
spontaneous apoptosis of thymocytes.
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