Acta
Medica Medianae
Vol. 45
Number 2, April, 2006
UDK 61
YU ISSN 0365-4478
Contact:
Julija
Radojicic
"ORTODENT"
24 Orlovic Pavle Street
18000 Nis, Serbia
Tel.: 018/ 521–912
E-mail:
ortodent@bankerinter.net
Copyright 2006
by Faculty of Medicine, University of Nis
|
INFECTIONS AND
ANAEMIA IMPACT ON THE CLEFT LIP AND PALATE DEVELOPMENT
Julija Radojicic, Tatjana
Tanic, Bozidar Radojicic and Andrija Radojicic
„ORTODENT"* in
Nis
Clinic of Dentistry of Nis**
The
risk factors that lead to development of the cleft lip and palate act
very early, between the 4th and 12th week of intrauterine development.
Most women in this ultimately critical period are unaware of being
pregnant. Therefore, insufficient attention is being paid to the risk
factors they are exposed to in that period, and which can lead to
numerous fetus anomalies, among which one of the most significant is
cleft lip and palate. The time to take actions is short and the reaction
often late. It is necessary to identify the risk factors in the
development of the cleft lip and palate, and prevent their damaging
effects.
Hereby, we present the study of the influence of infections and chronic
diseases on a mother in pregnancy. The investigation included children
born in the period between March 1999 and December 2003, together with
their parents. The study group comprised 96 children with the lip and
palate anomalies, all treated at the Gynaecology Clinic in Nis
(Neonatology ward), VMA (Military Medical Academy) Belgrade (Plastic
Surgery Institute), Institute for Mother and Child Protection, New
Belgrade, and the Children's Clinic in Tirs Street, Belgrade. The
control group consisted of 142 healthy children.
During the first quarter, almost 40% of the mothers in the study group
had viral infections (influenza), which is statistically significantly
more in relation to only 6,34% of the mothers in the control group (p <
0,001). The results concerning infections as a possible risk factor in
the development of the cleft lip and palate correspond with the results
of other studies that dealt with the very same issue. It has been
confirmed that this, seemingly harmless, yet very frequent illness in
our area, can have catastrophic consequences to fetus.
The results indicated that the mothers in the study group had more often
chronic diseases (p < 0,05), and in both groups anemia was statistically
most pre-sent (p < 0,05). The presence of anemia in the study group is
on the verge of signi-ficance (p=0,05) as related to the control one. It
is important to note that anemia is for the first time described in
literature as a possible risk factor in the development of the cleft lip
and palate. Acta Medica Medianae
2006;
45(2):33-36.
Key
words:
infection, anemia, cleft lip and palate, prevention |