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Acta
Medica Medianae Contact:
Copyright 2006 by Faculty of Medicine, University of Nis |
BIOEQUIVALENCE STUDIES Mihajlo B Jakovljević and Slobodan M Janković Department of clinical and experimental Farmacology of Faculty of Medicine in Kragujevac Development of pharmaceutical technology and occurence of different dosage forms and routes of administration of the same, well-known drugs leaded to greater role of bioequivalence testing. In this review, we would like to emphasize some aspects of bioequivalence testing between brand name and generic drug forms in both in vitro and in vivo conditions. We also consider important to present some examples of negative bioequivalence from marketed products in the past, together with the serious cosequences of their use. Acta Medica Medianae 2006; 45(4):50-55. Key words: bioequivalence, brand-name drug, generic drug, formulation, phar-maceutical technology |