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Acta
Medica Medianae
Vol. 45
No 4, October, 2006
UDK 61
YU ISSN 0365-4478
Contact:
Zorana Deljanin
Health Care
Institute of Nis
50 dr Zoran Djindjic Street
18000 Nis, Serbia
Phone: 018/ 226 448, lokal 152
E-mail:
zoranam@bankerinter.net
Copyright 2006
by Faculty of Medicine, University of Nis
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FAMILY HISTORY OF DISEASE AS A RISK FACTOR OF ACUTE
MYOCARDIAL INFARCTION
Zorana Deljanin, Natasa
Rancic, Branislav Tiodorovc, Branislav Petrovic, Mirko Ilic, Zoran
Velickovic and Roberta Markovic
Health Care
Institute of Nis
Myocardial infarction
(MI) is a complex disease that begins with a lifelong interaction between
genetics and environmental factors. The aim of the study was to identify
family history as a risk factor of myocardial infarction in examined
population in the Municipality of Nis.
We used a case-control study with 100 patients with a first MI (in the
period 1998-2000) and 100 controls, matched with respect to sex and age (±
2 years) from the Municipality of Nis.
Data was obtained from the epidemiological questionnaire. The Yates
c2
test, odds ratio-OR and their 99% interval of confident were used as
statistical procedures.
The results showed that statistical significance for MI was present among
all three degrees of relatives of subjects who have had an acute MI, and
for hypertension, hypercholesterolemia and stroke among first and second
- degree relatives. The subjects with family history of
hypercholesterolemia had 12.43 times higher risk of disease (p = 0,000)
and in the case of family history of MI before the age of 55, the risk was
almost 10 times (p = 0,000) higher. Almost 4 times higher risk of disease
was registered in subjects with family history of hypertension (p <
0,00001) and stroke (before 65 years of age) - (p < 00005); a two-fold
higher risk was registered in subjects with diagnoses of diabetes (p <
0,05) and other cardiovascular diseases (unless hypertension) (p < 0,01)
in the nearest relatives before the age of 55.
We concluded that family history of diseases on the sample of the
Municipality of Nis inhabitants was very important risk factor, mostly in
the first-degree relatives. Genetic epidemiology is the future for all
investigations between different population, and special attention should
be paid to investigations and findings of different genes and loci which
are very important for myocardial infarction occurrence, which would allow
a new approach to preventive medicine. Acta Medica Medianae
2006;45(4):5-14.
Key words:
family history, risk factor, acute myocardial infarction
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