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Acta Medica Medianae Correspondence to: Dhastagir Sheriff Department of Biochemistry Al Arab Medical Unviersity Benghazi, Libya E-mail: dhastagir@yahoo.ca
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Review article
SPERMATOZOA- AN UNIQUE REPRESENTATION OF OXYGEN-ANTIOXIDANT PARADOX
Elshaari F. A., Fatum A. E.and Sheriff D. S.
Department of Biochemistry, Al Arab Medical Unviersity, Benghazi, Libya
Infertility has become a common occurrence in males. Oxidant stress has become one of the most common causes of infertility. X-irradiation, or exposure to environmental toxicants and the physical conditions of varicocele and cryptorchidism have been demonstrated to increase testicular oxidative stress. The resultant oxidant stress may lead to an increase in germ cell apoptosis and subsequent hypospermatogenesis. This may result in changes in the dynamics of testicular microvascular blood flow, endocrine signaling, and germ cell apoptosis. Oxidative stress, therefore, becomes a major and the most probable finding associated with male infertility. This raises a possibility of application of antioxidant therapy that could help alleviate the reduced spermatogenesis. Acta Medica Medianae 2010;49(1):48-53.
Key Words: oxidative stress, testis, male infertility, apoptosis
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