Acta Medica Medianae
Vol. 49, No 3, September, 2010
UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)
 

Correspondence to:

Clinic of Otorhinolaryngology

Department of Rhinology

Military Medical Academy

Crnotravska 17, 11040 Belgrade, Serbia

E-mail: alexneta@sezampro.rs

Original article
UDC: 616.211-006.5-07:57.083.32

INFLUENCE OF ALLERGY ON  CYTOKINE LEVEL IN NASAL DISCHARGE OF PATIENTS WITH NASAL POLYPS

Aleksandar Perić, Danilo Vojvodić and Olivera Miljanović

                         Clinic of Otorhinolaryngology, Military Medical Academy, Belgrade, Serbia¹

                         Institute of Medical Research, Department of Clinical Immunology, Military Medical Academy,

                         Belgrade, Serbia²

                         Center for Human Genetics and Immunology, Clinical Center of Montenegro, Podgorica, Montenegro³

Cytokine levels in nasal discharge reflect the inflammatory status of the nasal mucosa. The aim of the paper was to compare the concentrations of cytokines in nasal discharge in allergic and non-allergic patients with nasal polyps (NP). Thirty patients with NP (13 atopic and 17 non-atopic) were included in this study. Samples of nasal discharge were collected from nasal cavities of all 30 subjects. The levels of TNF-α, TNF-β, IL-1β, IL-2, IL-12, IFN-γ, IL-4, IL-5, IL-6, IL-10, and IL-8 in nasal discharge were measured using commercial flow cytometric kit. We found significantly higher concentrations of IL-4 (p<0.01), IL-5 (p<0.05), IL-6 (p<0.05) and TNF-β (p<0.05) in allergic patients with NP than in non-allergic. Polyps in non-atopic and atopic patients have different immunological patterns.  Acta Medica Medianae 2010;49(3):40-44.

Key words: allergy, cytokines, nasal polyps