Acta Medica Medianae
Vol. 50, No 2, June, 2011
UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)
 

Correspondence to:

Jadranka Odović

Faculty of Pharmacy

Vojvode Stepe 450

11221 Beograd, Srbija

jodovic@pharmacy.bg.ac.rs

Original article

UDC: 615.03:616.381-78

doi:10.5633/amm.2011.0202      

ELIMINATION OF ANGIOTENSIN – CONVERTING ENZIME INHIBITORS BY PERITONEAL DIALISATE

 Jadranka Odović¹ and  Jasna Trbojević-Stanković²

University of Belgrade, Faculty of Pharmacy, Belgrade, Serbia¹

Department of Hemodialysis, Clinic of Urology, Clinical Hospital Centre “Dr. Dragisa Misovic” , Belgrade, Serbia²

Angiotensin-converting enzyme (ACE) inhibitors are a significant group of drugs that are primarily used in the treatment of hypertension and congestive heart failure. Even though they belong to the same group of drugs and have similar efficacy, ACE inhibitors exhibit different pharmacological characteristics. The lipophilicity is one of the most important properties of biologically active substances. It influences their absorption, distribution, tissue penetration, action, elimination. In this paper, the elimination of ACE inhibitors by peritoneal dialisate in patients on peritoneal dialysis was investigated. The influence of ACE inhibitors' hydrophibicity in this way of elimination was discussed. Acta Medica Medianae 2011;50(2):12-17.

      Key words: angiotensin-converting enzyme inhibitors (ACE inhibitors), peritoneal dialysis,

elimination, lipophilicity