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Acta Medica Medianae
Vol. 50, No 3, September, 2011

UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Aleksandar Kostić

Clinic of Neurosurgery

Clinical Center Niš

Bul. dr Zorana Đinđića 48

18000 Niš, Serbia

E-mail: aleko018@yahoo.co.uk

Original article                                                              

UDC: 616.714.1-001.5:616.12-008.331.1






Aleksandar Kostić1, Ivan Stefanović1, Vesna Novak1, Aleksandar Igić1, Boban Jelenković1 and Goran Ivanov2


Clinic of Neurosurgery, Clinical Center Niš, Niš, Serbia1

Center for Anestesiology, Clinical Center Niš, Niš, Serbia2




There are several reasons of intracranial pressure (ICP) increase in the brain trauma. Brain edema, due to the brain-blood bariere injury, contusion of brain tissue and intracranial hematomas that represent mass lesion, cerebrovascular autoregulation failure which leads to hemodinamic disorder, and traumatic subarchnoid haemorrhagae that is commonly associated with CSF flow disturbances are the main causes. The aim of our study was to examine the survival of patients with severe brain trauma in the presence of different values of ICP. This prospective study included 32 patients with intracranial pressure monitored, and appropriate treatment undertaken. Twenty-two patients (68.75%) had elevated ICP, and in 10 patients (31,25%) there were no criteria of intracranial hypertnesion (ICHTN). The results of our study showed that absolute lethal value of ICHTN is 50mmHg and over – none of the injured survived such ICP if lasted more than two hours, because of inevitable brain and brainstem ischemia and failure of the vital functions. The relatively lethal values of ICP ranged from 40 to 50mmHg, in the case of which we menaged to prevent a fatal outcome in one out of five cases.  Acta Medica Medianae 2011;50(3):10-15.


      Key words: traumatic brain injury, intracranial monitoring, intracranial hypertension