Review article                                                         

UDC: 616.1-08:613.72:616-008.9

doi:10.5633/amm.2012.0309

 

 

CHANGES IN LIPOPROTEIN INDICATOR AND INDICATOR OF ENDOTHELIAL FUNCTION AFTER IMPLEMENTED CARDIOVASCULAR REHABILITATION PROGRAM

 

Olivera Krstić¹, Igor Ilić², Jasmina Ranković³, Gorana Nedin Ranković⁴, Nataša Đinđić⁴, Todorka Savić⁴, Slađan Karalejić², Branimir Mekić², Vesko Milenković² and Dragan Toskić²

Municipality of Niš, Serbia¹

University of Priština, Faculty of Sport and Physical Education, Leposavic, Serbia²

Primary Health Care Center Niš, Serbia³

University of Niš, Faculty of Medicine, Niš, Serbia⁴

 

Insufficient physical activity in the world annually is the cause of death of 1.9 million people. According to the data from the World Health Report, physical inactivity is about to become the global problem. Regular physical activity and good physical shape raise the functional capacity and the quality of patient’s life. With physical activity it is possible to improve metabolic, endothelial, lateral-muscular, pulmonary and cardiovascular functions of an organism, but also the function of the autonomous nervous system. The endothelium has the important role in maintaining the normal cardiovascular tonus and blood fluidity by reducing the platelet activity and the adhesion of leukocytes, and also by restricting the reaction of vascular inflammation. The aim of this paper was to present the recent data about effects of cardiovascular rehabilitation and physical training on lipoproteins’ status and markers of endothelial function.

The impact of physical activity on the lipid status is accomplished by affecting the enzymes of lipoprotein metabolism, including the lipoprotein and the liver lipase and the movable protein of cholesterol ester (11). The studies point out that aerobic physical activity result in increasing of HDL concentration  and the decrease of the triglycerides value, total and LDL cholesterol. The connection, which is dose-dependant, exists between physical activity and the lipid level, as the arguments which suggest that the duration of physical activity is the key parameter in modification of the lipid metabolism.

Physical activity leads to the beneficial changes in the cardiovascular and lipid indicators and improves the endothelial function in the secondary prevention of coronary disease. Reduction of the lipid parameters by introducing physical rehabilitation and dietetic regime lie in the basis of secondary prevention of coronary disease. Furthermore, there is a constant improvement in NO biodisposability and therewith the improvement in endothelial function. Acta Medica Medianae 2012;51(3):52-56.

 

      Key words: carcinoid, gastrointestinal tract, neuroendocrine tumours, serotonin, carcinoid syndrome