Original article                                          UDC: 577.1:616.36-008.6]:616.366-003.7

                                                                     doi:10.5633/amm.2014.0102

 

 

Connection between markers of cholestasis and intensity of oxidative modification of proteins in patients with choledocholithiasis

 

Zoran Damnjanović¹, Milan Jovanović^1,2, Aleksandar Nagorni^2,3, Dušan Sokolović², Milan Radojković^2,4, Goran Damnjanović⁵, Boris Đinđić², Dragutin Grozdanović¹, Mlađan Golubović¹

 

 

Vascular Surgery Clinic, Clinical Center Niš, Serbia¹

Faculty of Medicine, University of Niš, Serbia²

Clinic of Gastroenterology and Hepatology, Clinical Center Niš, Serbia³

General Surgery Clinic, Clinical Center Niš, Serbia⁴

Department of Internal Medicine, Military Hospital Niš, Serbia⁵

 

The aim of this study was to examine the connection between cholestatic markers and the oxidative protein modification intensity in patients with choledocholithiasis. All the participants were subjected to clinical, laboratory and ultrasonic check-up at the Internal Department of the Military Hospital in Niš, Serbia. The parameters of oxidative stress: carbonyl groups, a measure of oxidative protein modification, and biochemical markers of cholestasis were determined by standard biochemical methods. The concentration of total (r=0.41, p<0.05), direct (r=0.49, p<+0.01) and indirect (r=0.41, p<0.05) bilirubin was in statistically significant positive linear correlation with the intensity of oxidative modification of proteins, while the other biochemical markers of cholestasis did not show such correlation. Total, direct and indirect bilirubins showed a significant positive correlation with oxidative protein modification, assessed through the levels of carbonyl groups in patients with choledocholithiasis. Acta Medica Medianae 2014;53(1):10-14.

 

Key words: cholestasis, intensity of oxidative modification of proteins, choledocholithiasis