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ACTA
STOMATOLOGICA
NAISSI

 Table of Contents for
Decembar 2015 • Volume 31 • Number 72

PTHE ROLE OF GROWTH FACTORS IN

EXTRACTION WOUND HEALING

Simona Stojanović1

Miloš Tijanić1,2

Goran Jovanović1,2

Milan Spasić2,4

Branislava Stojković1,3

Milica B.Petrović4

Tijana Denčić1,5

1 University of Niš, Faculty of Medicine Niš
2 CLINIC OF DENTISTRY, DEPARTMENT OF ORAL SURGERY, NIŠ, SERBIA
3 CLINIC OF DENTISTRY department for CHILDREN AND PREVENTIVE DENTISTRY
 4 ph.d.student, Faculty of Medicine ,University of Niš
5 CENTER FOR PATHOLOGY AND PATHOLOGICAL ANATOMY, NIŠ, SERBIA
   
...Abstract


 

Background: Wound healing is a complex process  that includes hemostasis, inflammation, proliferation and tissue remodeling. Growth factors are natural biological mediators that regulate crucial cellular processes involved in the tissue repair, such as DNA synthesis, angiogenesis, metabolic activity, migration, chemotaxis, proliferation, differentiation and matrix synthesis. The most important growth factors that play a part  in the extraction-wound healing process  and bone tissue regeneration are: platelet - derived growth factor-PDGF, transforming growth factor Beta-TGF β ,insulin- like growth factor-IGF, bone morfogenetic protein-BMP-2, BMP– 7 ,vascular endothelial growth factor- VEGF, fibroblast growth factor-FGF. Growth factors appear at various concentrations at different times, so that  the wound age may be estimated by their age. Execpt wound healing growth factors may be used in better oseointegration of imlants, alveolar ridge augmentation, alveolit etc. Studies of physiological processes in which growth factors have a regulatory role indicate that these molecules rarely act in biological isolation. The study of the interaction between the growth factors in the alveolar bone can explain tissue ability to heal even under adverse conditions, such as infection and radiation.
Key words: growth factors, extraction wound, healing

 
... Authors and Reprint Information

Address of correspondence:
Simona Stojanović, DDS,
Faculty of Medicine Niš,
Dr Zoran Djindjić Bld 81,
Niš, Srbija
E-mail: tarana.simona@gmail.com



Copyright © 2015 by The Editorial Council of The Acta Stomatologica Naissi