SALIVA CONTENT IN ORAL DERMATOLOGICAL LESION

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ACTA
STOMATOLOGICA
NAISSI

Table of Contents for
Decembar 2015 • Volume 31 • Number 72

SALIVARY HUMORAL CHANGES

IN ORAL BULLOUS LICHEN PLANUS

Mirjana Popovska1,

Ana Minovska2,
Vera Radojkova-Nikolovska1,
Ilijana Muratovska1, Biljana Kapuševska1,
Pavlina Aleksova1, Spiro Spasovski3

¹UNIVERSITY ST. CYRIL AND METHODIUS, FACULTY OF DENTISTRY, 1000 SKOPJE, REPUBLIC OF MACEDONIA

²UNIVERSITYGOCEDELČEV, FACULTY OF MEDICINE, 1000 ŠTIP, REPUBLIC OF MACEDONIA

³PRIVATE DENTAL OFFICE „FJOLLAMEDIKA”, 1000 SKOPJE, REPUBLIC OF MACEDONIA

...Abstract

Background: To investigate the salivary humoral mechanisms in patients with bullous lichen planus, in the phases of exacerbation and remission.

Material and Methods: Nineteen patients with bullous oral lichen planus were followed. Saliva was collected in the morning without stimulation in the amount from 5-10 cm². The determination of immunoglobulins, C3 and C4 in the saliva was performed using the micro-ELISA technique. The circulating immune complexes in the serum and saliva were determined by the PEG method. The results were compared with a control group and within the group in the phases of exacerbation and remission. The results were statistically processed by Student’s t - test .
Results: Salivary IgA showed a significant decrease, whereas IgG and IgM significantly increased. The values of immunoglobulin A, G and M in the phase of remission were significantly increased compared with the control group.
By comparing salivary immunoglobulins in the phases of exacerbation and remission, identical amounts of IgG in both stages of the disease were observed. However, considerably elevated values of IgA and slightly significant increase in the values of IgM were noted. CIC values in the control group and in patients’ group in the phases of exacerbation and remission were increased. Data suggest a highly significant depression of C3 component in the exacerbation phase, while in remission a slightly significant decrease was evident. Complement component C4 in the remission phase compared with a control group was declined.
Conclusion: There is an evident involvement of certain saliva components in the pathogenesis of oral lichen planus, but the final predominance of humoral mechanisms in the pathogenesis of bullous lichen planus does not exist yet.

Key words: bullous oral lichen planus, salivary immunoglobulins, complement

... Authors and Reprint Information

Address of correspondence:
Mirjana Popovska , Prof, PhD,
University St. Cyril and Methodius, Faculty of dentistry,
MajkaTereza bb, 1000 Skopje, Republic of Macedonia,
E-mail: popovskam2002@yahoo.com
Tel:+38970519304