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ACTA
STOMATOLOGICA

NAISSI

Table of Contents for
December 2007 • Volume 23 • Number 56

SEM ANALYSIS OF THE OSTEOPOROTIC ALVEOLAR BONE
INDUCED BY CORTICOSTEROID TREATMENT

Scientific article

 

Zorica R. Ajduković1*,
Vojin P. Savić2,
Stevo J. Najman2

1MEDIcAL fAcULTy, cLINIc Of STOMATOLOgy, DEPARTMENT Of PROSTODONTIcS Of NIS, SERbIA
2MEDIcAL fAcULTy, INSTITUTE fOR bIOMEDIcAL RESEARch Of NIS, SERbIA

   
...Abstract


Osteoporosis is a very frequent pathological state of the bone system which appears as a result of numerous metabolic disturbances and in some cases of the negative influence of the therapeutic factors. The research was performed on Wisstar rats, female, 6-8 weeks old. The experimental animal group was treated by cortico-preparations. After that period one part of the experimental group was sacrificed and the rest was divided into two groups: control (without corticosteroid treatment) and experimental group treated by the recovery therapy (Calcimu gluconat, Timus extract, and spontaneous recovery). After 15 weeks of experiment the animals were sacrificed, bone tissue samples of the rats’ lower jaw were taken, prepared and SEM analyzed. SEM showed that trabeculae became thinner, the number of spongious bone traebeculae was reduced and marrow spaces increased as the result of corticopreparation influence on the alveolar bone of the rats’ lower jaw. After the cortico-therapy and transition to therapy of spontaneous recovery, spongious bone of mandible positively reacted, and rough surface of bone, trabeculae of various dimensions, forms and localizations and one polymorphia were noticed. These changes represented slow decrease of resorptive process and increased recovery of bone tissue with process of osteogenesis prevailing. As soon as recovery therapy started, spongiuos bone reacted favorably as it was naticed by SEM. Trabeculae were polymorphic, variable in size, shape and arrangement, normal in appearance and size, marrow spaces were of usual size, and bone surface was unequal. Using SEM analysis the recovery by thymus extract showed: enlarged surface matrix, cell density and cell activity (osteoclastic activity). According to the achieved results, it can be concluded that corticopreparations after a long use can lead to decalcification and reduction of bone tissue trabecular number, i.e. bone dilution and resorption, while the recovey therapy showed partial success in the examined period.

Key words: SEM, alveolar bone, osteoporosis, rat.
 

...Authors and Reprint Information

Ass. Prof. Zorica Ajduković, DDS, MSD, PLD
2/21 Toplička  Street
18000 Niš, Serbia
E-mail: ajdukovic@sbb.co.yu


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