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Introduction: Prostatitis is one of
the most chronic diseases which is often associated with periodontitis.
The serum Prostate Specific Antigen (PSA) levels can be elevated in a
non-malignant condition such as symptomatic and asymptomatic prostatitis.
Similarity in the inflammatory etiopathogenesis of these diseases is
evident through the presence of Gram negative bacteremia, which in turn
may be the possible link between these two conditions.
Aim: To estimate the possible association between chronic
periodontitis and prostatitis, evaluating the PSA levels in patients
with moderate and severe periodontitis.
Material and methods: 40 patients with prostatitis and elevated
Prostate Specific Antigen (PSA) levels (≥ 4ng/ml) that participated in
the study were hospitalized at the University Urology Clinic at the
Faculty of Medicine in Skopje. Patients were divided into two groups on
the basis of the levels of periodontal clinical attachment. First group
of 20 patients with Clinical attachment level (CAL) ≥ 3mm, moderate
periodontitis and other group of 20 patients with CAL ≥ 5mm, severe
periodontitis. Dental plaque index (DPI), Index of gingival inflammation
(IGI), Gingival bleeding index (GBI) and Clinical attachment level (CAL)
were recorded and an assessment of PSA values was done and correlation
to periodontal parameters, respectively. Differences in means, as
statistically significant, were analyzed using Student's t- test. The
relationship between PSA scores with all clinical parameters was done
using Pearson's correlation coefficient technique.
Results: Statistically significant differences were noted, (p<0.05)
between periodontal index values (DPI, IGI, GBI, CAL) and PSA levels
within the two examined groupsHigher PSA levels were recordedin patients
with severe periodontitis than inthose with moderate periodontitis.
Pearson coefficient test among these periodontal indices (DPI, IGI, GBI
and CAL) and PSA levels in two examined groups showed no statistically
significant correlation.
Conclusion: Patients with severe periodontitis were found to have
higher PSA levels than those with moderate periodontitis. The clinical
parameters of periodontitis and elevated PSA levels indicated a probable
link between the two diseases.
Key words:
periodontitis; prostate specific
antigen; prostatitis
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Address of correspondence:
Emilija Stefanovska DDM, MSD, PhD
Department of Periodontology and Oral Medicine,
Faculty of Dentistry,
University “Ss Cyril and Methodius” Skopje, Macedonia
e-mail:emistefanovska@yahoo.com
Phone number:+38923299004
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