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Introduction: Sinusitis is an
inflammation of the paranasal sinuses and it can be infectious, allergic
or autoimmune. Acute rhinosinusitis commonly has viral origin and occurs
as part of the upper respiratory tract infections. The most common
pathogens are Streptococcus, Pneumococcus and Haemophilus influenzae.
Some inflammations may start as viral, but develop into bacterial
superinfection, i.e., subsequent colonization of the bacteria in 0.5-2%
of cases. Viral sinusitis lasts for 7–10 days, whereas bacterial may
take longer.
The aim: The aim of this study was to compare three therapeutic
protocols for the treatment of acute bacterial rhinosinusitis.
Materials and Methods: A prospective clinical study was conducted
at the Ear, Nose and Throat Clinic, Clinical Center Nis from October
2019 to January 2020, and it involved patients with acute bacterial
rhinosinusitis in whom we compared the efficiency and safety of
levofloxacin administration for five and 10 days with the efficiency of
amoxicillin clavulanate treatment. The study included 62 patients with
documented clinical and radiological symptoms.
Results: Confirmation of bacterial etiology is not routinely
performed in clinical practice since it requires antral puncture or
endoscopic examination of the middle nasal meatus. Consequently, the
choice of antibiotic therapy is empiric. In our study, we used
levofloxacin for five (500 mg once a day) and 10 days (500 mg once a
day) and amoxicillin-clavulanatefor 10 days (500 mg–125 mg three times a
day), and the results showed no statistically significant difference in
regard to the choice of antibiotics and the duration of therapy.
Conclusion: The findings of this study suggest that a short
course of antibiotic treatment has similar efficiency compared to a
longer course of treatment of patients with uncomplicated acute
bacterial sinusitis when treatment is indicated.
Key words:
acute rhinosinusitis, antibiotics, therapy
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Address of correspondence:
Assistant prof. Mila Bojanović, M.D,
PhD
Faculty of Medicine Niš
Clinic of Otorhinolaryngology
Blvd Dr Zorana Djindjić 81, 18000 Niš
E-mail: milabojanovic@yahoo.com
Copyright © 2022 by The Editorial Council of The Acta
Stomatologica Naissi |