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Background: Hyperparathyroidism (HPT)
is a common endocrine disorder with potential complications on the
skeletal, renal, neurocognitive and cardiovascular systems. Its
association with the lack of osseointegration of dental implants hasnot
been describedin the medical literature.
Case presentation: This case report aims to discuss two cases of
dental implant loss in which a high level of parathormone (PTH) was
found in the absence of any other systemic or local comorbidity,
suggesting the possible correlation between HPT and implant.Both
patients were referred to the clinic complaining about prosthetic
complications, gingival inflammation and mobility of the dental
prosthesis. After a Cone-Beam computed Tomography evaluation, all
implants of both patients were removed for rejection arising from
periimplantitis and then four implants were inserted in the patient 1
and five implants in the patient 2. For both patientsshort implants (Bicon
LLC, Boston, Massachusetts, USA), featured by 4 mm in diameter and 5 mm
in height, were used and the prosthesis substructure was made of Trinia®
(Bicon LLC, Boston, Massachusetts, USA). During the fifth year, the
patients reported complications and the implant treatment failure. In
order to establish the causes of failure, a thorough investigation was
performed. Since no causes were detected, the patients were required to
perform a blood test to evaluate bone metabolism and specifically to
assess parathyroid-hormone levels (PTH), calcium levels and vitamin D.
Results: The results of the blood tests showednormal calcemia,
vitamin D deficiency and elevated PTH levelsin both patients. After an
endocrinologist’s consultation, secondary hyperparathyroidism was
diagnosed.
Conclusion: It is reasonable to assume that the loss of
osseointegration of dental implants can be correlated with the effects
of HPT.
Key words:
dental implants, hyperparathyroidism, implantology, osseointegration,
parathormone
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Address of correspondence:
Alessio Zanza DDM,
Prof Luca Testarelli, D.M.D, PhD
Department of Oral and Maxillo-Facial Sciences,
Sapienza University of Rome,
Viale Regina Elena 287a, 00161 Rome, Italy
e-mail.alessio.zanza@uniroma1.it
e-mail.luca.testarelli@uniroma1.it
Copyright © 2022 by The Editorial Council of The Acta
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