THE SIGNIFICANCE OF SALIVARY CATIONIC

Home

Current Issue

Previous Issues

Subscription

Guidelines

Founders of ASN

Contact ASN

ACTA
STOMATOLOGICA
NAISSI

Table of Contents for
Decembar 2023• Volume 39 • Number 88

THE SIGNIFICANCE OF SALIVARY CATIONIC ANTIMICROBIAL PEPTIDES IN CARIES RISK ASSESSMENT IN CHILDREN: A LITERATURE REVIEW

Branislava B. Stojković,
Marija Lj. Igić,
Olivera R. Tričković Janjić,
Ana N. Igić,
Zorana M. Veličković,
Simona M. Stojanović,
Milica S. Petrović,
Miloš S. Kostić,
Nikola D. Živković,
Milan S. Spasić

¹University of Niš, Faculty of Medicine, Preventive and Pediatric Dentistry, Niš, Serbia
²Clinic of Dental Medicine, Niš, Serbia
³University of Niš, Faculty of Medicine, Oral Surgery, Niš, Serbia
⁴University of Niš, Faculty of Medicine, Oral Medicine and Periodontology, Niš, Serbia
⁵Faculty of Medicine, University of Niš, Institute of Immunology, Niš, Serbia
⁶University of Niš, Faculty of Medicine, Center of Pathology and Pathological anatomy, Clinical center Niš, Serbia

...Abstract

Introduction: Caries risk assessment is the essential step in the modern clinical approach to caries management. It is a basic prerequisite for the development of preventive measures and strategies for the primary prevention of caries. Its reliability is conditioned by the knowledge of relevant caries risk factors - indicators and predictors of caries.
Aim: After reviewing the available literature, the paperwork aimed to analyse the importance of salivary levels of cationic antimicrobial peptides as indicators and predictors of caries in children, i.e., their possible role in caries risk assessment in children.
Material and methods: The analysis included original articles in English which studied the association of salivary levels of cationic antimicrobial peptides with caries in children. Three databases were selected: PubMed, Scopus, and Web of Science, and the search was performed using the following keywords: saliva cationic peptides /antimicrobial peptides /AMP/ defensins/ cathelicidin/histatin/statherin/adrenomedullin/azurocidin AND dental caries AND children/children age.
Conclusion: Cationic antimicrobial peptides could be important caries risk indicators in children. Unfortunately, there is currently no reliable evidence of their caries predictive value. Well-designed cross-sectional and long-term longitudinal studies are still required to clarify the significance of salivary cationic antimicrobial peptides as reliable caries risk indicators and caries predictors in children. At the same time, this would define their significance as caries risk biomarkers and their potential application in caries risk assessment in children.

Key words: saliva, caries, cationic antimicrobial peptides, caries risk indicators, caries predictors

...Authors and Reprint Information

Address of correspondence:
Assitent Prof. Branislava B. Stojković, DMD, PhD
University of Niš, Faculty of Medicine
Clinic of dental medicine, Preventive and pediatric dentistry
81 Dr Zorana Djindjića Blvd.
E-mail: branislava.stojkovic@medfak.ni.ac.rs
Phone:+381637012340