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Introdudction: Carcinoma of
the stratified squamous epithelium of the oral cavity - oral squamous
cell carcinoma (OSCC) is an invasive pathological lesion of the
epithelium with varying degrees of squamous differentiation. It is
characterized by early and extensive metastases, infiltration of
adjacent anatomical structures, frequent recurrences, and a relatively
low five-year survival rate of less than 50%.
The aim of the study to determine the correlation between the
analysis of the lymphocytic infiltrate of biopsy specimens with
pathohistologically proven metastases of oral squamous cellular
carcinoma on postoperative neck dissection specimens.
Material and methods: The study included 42 patients with
pathohistologically verified oral squamous cellular carcinoma who
underwent surgery at the Department of Maxillofacial Surgery of the
Clinic of Ddental medicine in Niš in the period from 2018 to 2022. The
histopathological analysis included the depth of tumor invasion,
histopathological analysis of the lymph nodes of neck dissections,
analysis of lymphocytic infiltration, and presence of lymphovascularand
perineural invasion.
Results: It was determined that the depth of invasion is
statistically significantly different regarding the degree of
lymphocytic infiltration (p=0.004). Invasion of over 4mm was present in
20% of patients with high infiltration, 44.4% of patients with medium
infiltration, and 85.7% of patients with low infiltration.
Conclusion: Given that the results of the study indicate that the
analysis of the lymphocytic infiltrate can be a reliable predictive
factor of the appearance of metastases in the lymph nodes of the neck,
further research should be directed towardas sociating lymphocytic
infiltration with certain biochemical and genetic parameters based on
which a plan can be created for neck treatment in the N0 stage of oral
squamous cellular carcinoma.
Key words:
lymphocytic infiltration, oral squamous cell carcinoma, surgical
treatment
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Address of correspondence:
Milos Trajković, MD, DMD, PhD
student
Clinic of Dental Medicine Department of Maxillofacial
Surgery, Niš
52 Dr Zoran Djindjić Blvd, 18000 Niš, Serbia
Email dr.mtrajkovic@yahoo.com
Phone +381643458997
Copyright © 2023 by The Editorial Council of The Acta
Stomatologica Naissi
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