Introduction: Cancer is causing death
in countries with more or less economic development, and it is expected
that the burden will grow worldwide, especially in countries with less
developed populations, where about 82% of the global population lives.
The aim of this study was to present and estimate trends in
incidence, mortality rate and MIR of malignant neoplasm of otherand
ill-defined sites of lip, oral cavity and pharynx cancer in Central
Serbia from 1999 to 2020.
Material and methods: The registry-based study was conducted
using the data from the publically accessible Yearbooks of the Institute
of Public Health of Serbia: Incidence and Mortality in Central Serbia,
from 1999 to 2020. Joinpoint regression was used to determine the trend
and annual percentage change (APC) of the incidence and mortality rate
with corresponding 95% confidence intervals.
Results: A total number of 558 cases (436men and 122women) of
other and ill-defined lip, oral cavity and pharynx cancer sites
registered in Central Serbia from 1999 to 2020.
The crude rate (CR) and age-standardized rate (ASR-W) of incidence in
males increased (p<0.001, for both) during the study period with APC of
4.8% and 9.0%, respectively. The crude rate (CR) and age-standardized
rate (ASR-W) of mortality in males decreased (p<0.001, for both) during
the study period with APC of -7.5%, and -7.2%, respectively. The
mortality rate decrease was followed by the decline in MIR between 2001
and 2020 with anAPC of -5.6 (p<0.001).
Conclusions: Our results reveal that the incidence of other and
ill-defined lip, oral cavity and pharynx cancer sites in Central Serbia
increased through the study period. The mortality rate and MIR for this
cancer decreased during 22 years.
Key words:
ill-defined sites of lip, oral cavity and pharynx cancer; incidence
rate, mortality rate, cancer registry, trends
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Address of correspondence:
Assistant Prof. Aleksandra
Ignjatovic, MD, PhD
Institut of public Health
Dr Zoran Djindjic Blvd 50, Niš, Serbia
E-mail: drsalea@yahoo.com
Copyright © 2023 by The Editorial Council of The Acta
Stomatologica Naissi
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