PREVENTION OF BISPHOSPHONATE RELATED

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ACTA
STOMATOLOGICA
NAISSI

Table of Contents for
Decembar 2024 • Volume 40 • Number 90

PREVENTION OF BISPHOSPHONATE RELATED OSTEONECROSES OF THE JAW USING AUTOLOGOUS PLATELET CONCENTRATE

Biljana Evrosimovska^1,2,
Despina Veličkovska³,
Ana Gigovska-Arsova²,
Irena Stojanova²,
Vesna Jurukovska Šotarovska^4,5

¹“Ss. Cyril and Methodius university”, Faculty of Dentistry - Skopje, Department of Oral Surgery, sKOPLJE, north mAKEDONIA
²University Dental Clinical Centre “St. Pantelejmon” – Department of Oral Surgery and Implantology, sKOPLJE, north mAKEDONIA
³PRIVATE HEALTH CEARE ORGANISATION “edg2 3d – rtG DENTAL IMAGING”, sKOPLJE, north mAKEDONIJA
⁴ “Ss. Cyril and Methodius University”, Faculty of Dentistry - Skopje, Department of Prosthodontic
⁵University Dental Clinical Centre “St. Pantelejmon” - Department of Prosthodontics, sKOPLJE, north mAKEDONIA

...Abstract

Introduction: Platelet-rich fibrin (PRF) is now widely used in various fields of medicine, including tissue regeneration.
The aim of the work was to analyze the effect of PRF on improving postoperative wound healing in a patient with a risk of developing bisphosphonate osteonecrosis of the jaws.
Case report: A 71-year-old woman, who is on bisphosphonate therapy due to generalized osteoporosis, came to the clinic with an indication for surgical extraction of an impacted upper left canine. Oral surgical treatment was performed after a three-month interruption of therapy. During the surgical extraction of impacted teeth, a platelet-rich fibrin is placed and covered with a platelet-rich membrane.The wound healing was successful.
Conclusion: The use of PRF for oral surgical interventions in patients taking BPs appears to be a promising solution and an excellent alternative treatment for the healing of oral tissues. Key words: bisphosphonates, osteonecrosis, BRONJ, platelet-rich fibrin, oral surgical interventions.

Key words: bisphosphonates, osteonecrosis, bisphosphonate-related osteonecrosis of the jaw, platelet-rich fibrin, oral surgical interventions.

...Authors and Reprint Information

Address of correspondence:
Assoc. Prof. Biljana Evrosimovska, DDS, PhD
“Ss. Cyril and Methodius University”, Skopje, Faculty of Dentistry, Skopje, Department of Oral Surgery
4/21 Franklin Ruzvelt St. 1000 Skopje, North Macedonia
E-mail: bevrosimovska@stomfak.ukim.edu.mk