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Introduction
Medication-related osteonecrosis of the jaw (MRONJ) represents a new
pathological entity that appears as a side effect of medications used in
various diseases disrupting the normal homeostasis of bone tissue. This
type of osteonecrosis occurs as consequence of antiresorptive drugs,
primarily from the bisphosphonate group, but also other drugs that have
a different mechanism of action on bone tissue.
Aim was
to
point out the factors leading to the development of MRON, there are
many systemic factors, primarily endocrine and hormonal disorders, as
well as the body's immunodeficiency.
Rezults:
Risk factors for the development of MRONJ are interventions that involve
the bone tissue of the jaws, primarily tooth extraction, implant
procedures, curettage of the periodontal pocket, periapical operations,
etc. Prevention from MRONJ is carried out with a multidisciplinary
approach that involves the cooperation of rheumatologists, oncologists
and dentists. Coordinately applied multidisciplinary premedication
treatment reduces the incidence of MRONJ by 77.3%. Depending on the
stage of development of MRONJ, there are conservative and surgical
methods of treatment, which must be performed in a timely manner,
because the progression of the lesion leads to significant consequences
for the patient's health and life.
Conclusion:
Osteonecrosis of the jaw associated with the use of medicaments can be
an asymptomatic, indeterminate lesion that is very difficult to
diagnose, but without proper diagnosis and therapy it can develop and
turn into a more severe form, complicated for treatment, with a
pathological fracture of the jaw, mucocutaneous fistulas and large scars
and mutilation. Prevention and multidisciplinary pretreatment and
treatment are of key importance for reducing the occurrence and
progression of this lesion.
Key words:
osteonecrosis,medications, prevention, therapy
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Address of correspondence:
Simona Stojanović, DDS,PhD
University of Nis. Faculty of Medicine
Dr Zorana Djindjića Blvd 81, Nis, Serbia.
E-mail: tarana.simona@gmail.com.
Copyright © 2024by The Editorial Council of The Acta
Stomatologica Naissi
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