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Introduction
Medication-related
osteonecrosis of the jaw (MRONJ) represents a new pathological entity
that appears as a side effect of medications used in various diseases
disrupting the normal homeostasis of bone tissue. This type of
osteonecrosis occurs as consequence of antiresorptive drugs, primarily
from the bisphosphonate group, but also other drugs that have a
different mechanism of action on bone tissue.
Aim was to point out the factors leading to the development of
MRONJ.
Rezults: There are many systemic factors, primarily endocrine and
hormonal disorders, as well as the body's immunodeficiency. Risk factors
for the development of MRONJ are interventions that involve the bone
tissue of the jaws, primarily tooth extraction, implant procedures,
curettage of the periodontal pocket, periapical operations, etc.
Prevention from MRONJ is carried out with a multidisciplinary approach
that involves the cooperation of rheumatologists, oncologists and
dentists. Coordinately applied multidisciplinary premedication treatment
reduces the incidence of MRONJ by 77.3%. Depending on the stage of
development of MRONJ, there are conservative and surgical methods of
treatment, which must be performed in a timely manner, because the
progression of the lesion leads to significant consequences for the
patient's health and life.
Conclusion: Osteonecrosis of the jaw associated with the use of
medicaments can be an asymptomatic, indeterminate lesion that is very
difficult to diagnose, but without proper diagnosis and therapy it can
develop and turn into a more severe form, complicated for treatment,
with a pathological fracture of the jaw, mucocutaneous fistulas and
large scars and mutilation. Prevention and multidisciplinary
pretreatment and treatment are of key importance for reducing the
occurrence and progression of this lesion.
Key words:
osteonecrosis,medications, prevention, therapy
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Address of correspondence:
Simona Stojanović, DDS,PhD
University of Nis. Faculty of Medicine
Dr Zorana Djindjića Blvd 81, Nis, Serbia.
E-mail: tarana.simona@gmail.com.
Copyright © 2024by The Editorial Council of The Acta
Stomatologica Naissi
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