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ACTA
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Table of Contents for September 2003 • Volume 19 • Number 43 |
PREVENTION AND MEDICAL TREATMENT OF
ORAL MUCOSITIS
IN PATIENTS WITH ANTINEOPLASTIC THERAPY - PART II
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Vesna Branković, Dental clinic, department of oral medicine and periodontology, Niš |
| ...Abstract |
Mucositis, as the consequence of hemotherapy, radiation and combination of both methods of treatment, is important and difficult problem in the treatment of malign diseases, which can remarkably imperil and prolong antineoplastic treatment. Those which appear as the consequence of radio therapy in the area of head and neck, are direct cytotoxic effect of radiation. It is moderate for malign cells, but it damages also the normal healthy cells division of oral epithelium, as well as connective tissue cells and bone, which leads to disturbance of integrity of oral mucous. The problem becomes more serious by outer factors, at first by infection. Smears of oral mucous in patients with radiation in the head and neck area, show the increased colonization of Gram negative bacteria and fungi. Enterobacteria are the most frequent which appear of Gram negative ones, where the role of their endotoxin is intensified in causing inflammations and pseudomembranae, but also the role of fungi, especially those of Candida genus. Because of such difficult changings in oral mucosa, there is a permanent tendency to act by various medicaments but preventively, but if it happens that mucositis appears, the therapy will help to alleviate its difficulty and to enable the basic therapeutic process and reduce treatment expenses by reducing hospital days.
Key
words: mucositis, therapy, polichemio therapy, radiation |
| ...Authors and Reprint Information |
Copyright © 2003 by The Editorial Council of The Acta Stomatologica Naissi |